Drug interactions
Tolmetin + Valganciclovir
Severity: Minor
Tolmetin and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valganciclovir is converted to ganciclovir, which is renally eliminated by filtration and tubular secretion. Tolmetin may compete for secretion or reduce renal function, possibly raising ganciclovir exposure, though clinical impact is likely small.
What this interaction means in plain words
Tolmetin and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Tolmetin belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion and NSAID-related reduction in renal perfusion decrease ganciclovir clearance.
What to do
Monitor renal function and blood counts, and dose valganciclovir according to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Tolmetin with Valganciclovir?
MediHelp rates the interaction as minor. Tolmetin and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valganciclovir is converted to ganciclovir, which is renally eliminated by filtration and tubular secretion. Tolmetin may compete for secretion or reduce renal function, possibly raising ganciclovir exposure, though clinical impact is likely small.
How serious is the interaction between Tolmetin and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, and dose valganciclovir according to creatinine clearance.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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