Drug interactions
Tolvaptan + Triamterene
Severity: Moderate
Tolvaptan and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is an aquaretic and does not itself retain potassium; some labeling notes potassium increases, but the effect is small. Combined with triamterene, serum potassium may rise, so monitoring is sensible.
What this interaction means in plain words
Tolvaptan and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolvaptan belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene reduces renal potassium excretion, and tolvaptan may modestly raise potassium through changes in fluid and electrolyte handling.
What to do
Monitor serum potassium and sodium after starting the combination and periodically afterward. Reduce or stop triamterene if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Tolvaptan with Triamterene?
MediHelp rates the interaction as moderate. Tolvaptan and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan is an aquaretic and does not itself retain potassium; some labeling notes potassium increases, but the effect is small. Combined with triamterene, serum potassium may rise, so monitoring is sensible.
How serious is the interaction between Tolvaptan and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and sodium after starting the combination and periodically afterward. Reduce or stop triamterene if potassium rises.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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