Drug interactions
Tolvaptan + Valsartan
Severity: Moderate
Tolvaptan and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan is a vasopressin antagonist that is not itself a potassium-sparing agent, but labeling notes a possible rise in serum potassium with it. Combined with an ARB, which reduces aldosterone effect, potassium may rise further. Rapid fluid loss can also lower blood pressure and affect renal function.
What this interaction means in plain words
Tolvaptan and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tolvaptan belongs to Endocrine; Valsartan belongs to Cardiovascular.
Why it happens
ARB-induced reduction in aldosterone-mediated potassium excretion adds to a tolvaptan-associated potassium rise; the pharmacodynamic effects are additive.
What to do
Monitor serum potassium and renal function after initiating or changing doses. Also watch volume status and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Tolvaptan with Valsartan?
MediHelp rates the interaction as moderate. Tolvaptan and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolvaptan is a vasopressin antagonist that is not itself a potassium-sparing agent, but labeling notes a possible rise in serum potassium with it. Combined with an ARB, which reduces aldosterone effect, potassium may rise further. Rapid fluid loss can also lower blood pressure and affect renal function.
How serious is the interaction between Tolvaptan and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function after initiating or changing doses. Also watch volume status and blood pressure.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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