Drug interactions
Topiramate + Vardenafil
Severity: Minor
Topiramate and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak CYP3A4 inducer at higher doses and may modestly reduce vardenafil exposure. This could lessen the response to vardenafil, although the effect is usually small.
What this interaction means in plain words
Topiramate and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Topiramate belongs to Central Nervous System; Vardenafil belongs to Genitourinary.
Why it happens
Weak induction of CYP3A4-mediated vardenafil metabolism by topiramate.
What to do
Assess the erectile response; if efficacy is reduced, consider adjusting the vardenafil dose within the labeled range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Topiramate with Vardenafil?
MediHelp rates the interaction as minor. Topiramate and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topiramate is a weak CYP3A4 inducer at higher doses and may modestly reduce vardenafil exposure. This could lessen the response to vardenafil, although the effect is usually small.
How serious is the interaction between Topiramate and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess the erectile response; if efficacy is reduced, consider adjusting the vardenafil dose within the labeled range.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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