Drug interactions
Tranylcypromine + Trihexyphenidyl
Severity: Moderate
Tranylcypromine and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine has labeled cautions about anti-parkinsonian drugs, and trihexyphenidyl may add anticholinergic effects such as confusion, tachycardia, urinary retention and hyperthermia. MAO inhibitors may also worsen these effects in susceptible patients.
What this interaction means in plain words
Tranylcypromine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Tranylcypromine belongs to Central Nervous System; Trihexyphenidyl belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects, with anticholinergic burden combined with the sympathomimetic and monoaminergic effects of MAO inhibition.
What to do
Start trihexyphenidyl at a low dose and increase slowly. Monitor heart rate, blood pressure, temperature, mental status and urinary function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Trihexyphenidyl
Frequently asked questions
Can I take Tranylcypromine with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Tranylcypromine and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranylcypromine has labeled cautions about anti-parkinsonian drugs, and trihexyphenidyl may add anticholinergic effects such as confusion, tachycardia, urinary retention and hyperthermia. MAO inhibitors may also worsen these effects in susceptible patients.
How serious is the interaction between Tranylcypromine and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start trihexyphenidyl at a low dose and increase slowly. Monitor heart rate, blood pressure, temperature, mental status and urinary function.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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