Drug interactions
Tranylcypromine + Umeclidinium bromide / vilanterol inhaled
Severity: Major
Tranylcypromine and Umeclidinium bromide / vilanterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta2 agonist, can have cardiovascular effects potentiated by MAOIs, leading to tachycardia, palpitations, blood pressure changes and arrhythmias. Labeling advises extreme caution with MAOIs and for two weeks after stopping them.
What this interaction means in plain words
Tranylcypromine and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition increases catecholamine availability, augmenting the adrenergic cardiovascular effects of the beta2 agonist.
What to do
Prefer an alternative bronchodilator when possible. If used, monitor heart rate, blood pressure and ECG symptoms, especially at initiation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Tranylcypromine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as major. Tranylcypromine and Umeclidinium bromide / vilanterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vilanterol, a long-acting beta2 agonist, can have cardiovascular effects potentiated by MAOIs, leading to tachycardia, palpitations, blood pressure changes and arrhythmias. Labeling advises extreme caution with MAOIs and for two weeks after stopping them.
How serious is the interaction between Tranylcypromine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative bronchodilator when possible. If used, monitor heart rate, blood pressure and ECG symptoms, especially at initiation.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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