Drug interactions
Tranylcypromine + Vilanterol / fluticasone furoate inhaled
Severity: Major
Tranylcypromine and Vilanterol / fluticasone furoate inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta2 agonist, and MAOIs can potentiate its cardiovascular effects, causing tachycardia, hypertension, palpitations and arrhythmias. Labeling advises extreme caution during MAOI therapy and for two weeks after stopping.
What this interaction means in plain words
Tranylcypromine and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition increases catecholamine availability, augmenting the adrenergic effects of the beta2 agonist.
What to do
Consider alternative maintenance therapy where possible. If used, monitor heart rate and blood pressure and review for palpitations or chest symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Tranylcypromine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as major. Tranylcypromine and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vilanterol is a long-acting beta2 agonist, and MAOIs can potentiate its cardiovascular effects, causing tachycardia, hypertension, palpitations and arrhythmias. Labeling advises extreme caution during MAOI therapy and for two weeks after stopping.
How serious is the interaction between Tranylcypromine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider alternative maintenance therapy where possible. If used, monitor heart rate and blood pressure and review for palpitations or chest symptoms.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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