Drug interactions
Tranylcypromine + Yohimbine
Severity: Major
Tranylcypromine and Yohimbine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine blocks alpha-2 receptors and increases norepinephrine release, which with MAO inhibition can cause marked hypertension, tachycardia and anxiety. The combination is generally to be avoided.
What this interaction means in plain words
Tranylcypromine and Yohimbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Alpha-2 antagonism increases noradrenergic outflow while MAO inhibition prevents catecholamine breakdown.
What to do
Avoid the combination. If yohimbine has been taken, monitor blood pressure and heart rate and treat hypertension promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Tranylcypromine with Yohimbine?
MediHelp rates the interaction as major. Tranylcypromine and Yohimbine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbine blocks alpha-2 receptors and increases norepinephrine release, which with MAO inhibition can cause marked hypertension, tachycardia and anxiety. The combination is generally to be avoided.
How serious is the interaction between Tranylcypromine and Yohimbine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If yohimbine has been taken, monitor blood pressure and heart rate and treat hypertension promptly.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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