Drug interactions
Trastuzumab + Vincristine
Severity: Moderate
Trastuzumab and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy has been associated with a higher incidence of neutropenia and febrile neutropenia. Vincristine is only mildly myelosuppressive, but infection risk may still rise.
What this interaction means in plain words
Trastuzumab and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trastuzumab belongs to Oncology; Vincristine belongs to Oncology.
Why it happens
Additive hematologic toxicity when trastuzumab is combined with cytotoxic chemotherapy; no pharmacokinetic interaction is established.
What to do
Monitor blood counts and for signs of infection, and use supportive care such as growth factors or dose delays according to protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Trastuzumab with Vincristine?
MediHelp rates the interaction as moderate. Trastuzumab and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy has been associated with a higher incidence of neutropenia and febrile neutropenia. Vincristine is only mildly myelosuppressive, but infection risk may still rise.
How serious is the interaction between Trastuzumab and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection, and use supportive care such as growth factors or dose delays according to protocol.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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