Drug interactions
Trastuzumab + Vinorelbine
Severity: Moderate
Trastuzumab and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive chemotherapy such as vinorelbine has been associated with a higher incidence of neutropenia and febrile neutropenia. Infection risk therefore increases.
What this interaction means in plain words
Trastuzumab and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trastuzumab belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Additive hematologic toxicity of trastuzumab on top of chemotherapy-induced myelosuppression; mechanism not fully defined.
What to do
Monitor neutrophil counts regularly and manage neutropenia with dose delay, reduction or growth factor support per protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Trastuzumab
Frequently asked questions
Can I take Trastuzumab with Vinorelbine?
MediHelp rates the interaction as moderate. Trastuzumab and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive chemotherapy such as vinorelbine has been associated with a higher incidence of neutropenia and febrile neutropenia. Infection risk therefore increases.
How serious is the interaction between Trastuzumab and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts regularly and manage neutropenia with dose delay, reduction or growth factor support per protocol.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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