Drug interactions
Travelers diarrhea and cholera vaccine inactivated + Ustekinumab
Severity: Minor
Travelers diarrhea and cholera vaccine inactivated and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may blunt the immune response to vaccines, so protection from the inactivated cholera/travelers diarrhea vaccine could be reduced. Because the vaccine is inactivated, there is no risk of vaccine-strain infection, and the combination is not truly contraindicated.
What this interaction means in plain words
Travelers diarrhea and cholera vaccine inactivated and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Interleukin-12/23 inhibition by ustekinumab may modestly dampen vaccine-induced immune responses.
What to do
Inactivated vaccines may be given during ustekinumab therapy; where feasible, vaccinate before starting treatment. Do not rely on a reduced response for protection in high-risk travel and continue standard food and water precautions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Travelers diarrhea and cholera vaccine inactivated with Ustekinumab?
MediHelp rates the interaction as minor. Travelers diarrhea and cholera vaccine inactivated and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may blunt the immune response to vaccines, so protection from the inactivated cholera/travelers diarrhea vaccine could be reduced. Because the vaccine is inactivated, there is no risk of vaccine-strain infection, and the combination is not truly contraindicated.
How serious is the interaction between Travelers diarrhea and cholera vaccine inactivated and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inactivated vaccines may be given during ustekinumab therapy; where feasible, vaccinate before starting treatment. Do not rely on a reduced response for protection in high-risk travel and continue standard food and water precautions.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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