Drug interactions
Triamcinolone acetonide injectable + Zafirlukast
Severity: Minor
Triamcinolone acetonide injectable and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamcinolone is cleared by CYP3A4, and inhibitors can raise systemic exposure. With zafirlukast's weak inhibition, the effect is likely small, though repeated or high doses could increase corticosteroid effects.
What this interaction means in plain words
Triamcinolone acetonide injectable and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by zafirlukast may slow triamcinolone clearance.
What to do
No routine change is needed. Watch for corticosteroid excess such as Cushingoid features or hyperglycemia with repeated dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Triamcinolone acetonide injectable with Zafirlukast?
MediHelp rates the interaction as minor. Triamcinolone acetonide injectable and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triamcinolone is cleared by CYP3A4, and inhibitors can raise systemic exposure. With zafirlukast's weak inhibition, the effect is likely small, though repeated or high doses could increase corticosteroid effects.
How serious is the interaction between Triamcinolone acetonide injectable and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for corticosteroid excess such as Cushingoid features or hyperglycemia with repeated dosing.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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