Drug interactions
Triazolam + Verapamil
Severity: Moderate
Triazolam and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil increases triazolam exposure, causing deeper and longer sedation, psychomotor impairment and potential respiratory depression.
What this interaction means in plain words
Triazolam and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 by verapamil reduces first-pass and systemic clearance of triazolam.
What to do
Use a lower triazolam dose and monitor for excessive sedation, or choose a benzodiazepine not metabolized by CYP3A4 such as lorazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Triazolam with Verapamil?
MediHelp rates the interaction as moderate. Triazolam and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil increases triazolam exposure, causing deeper and longer sedation, psychomotor impairment and potential respiratory depression.
How serious is the interaction between Triazolam and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower triazolam dose and monitor for excessive sedation, or choose a benzodiazepine not metabolized by CYP3A4 such as lorazepam.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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