Drug interactions
Triazolam + Zafirlukast
Severity: Moderate
Triazolam and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is highly dependent on CYP3A4 and is sensitive to inhibitors. Zafirlukast may modestly increase its levels, causing stronger or prolonged sedation, impaired psychomotor performance and amnesia.
What this interaction means in plain words
Triazolam and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Zafirlukast weakly inhibits CYP3A4, reducing triazolam clearance.
What to do
Monitor for excess sedation and consider a lower triazolam dose. Counsel patients about next-day impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Triazolam and Zafirlukast, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Triazolam with Zafirlukast?
MediHelp rates the interaction as moderate. Triazolam and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is highly dependent on CYP3A4 and is sensitive to inhibitors. Zafirlukast may modestly increase its levels, causing stronger or prolonged sedation, impaired psychomotor performance and amnesia.
How serious is the interaction between Triazolam and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and consider a lower triazolam dose. Counsel patients about next-day impairment.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
