Drug interactions
Trifluoperazine + Ziprasidone
Severity: Contraindicated
Trifluoperazine and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both antipsychotics can prolong the QT interval. Using them together increases the risk of torsades de pointes and sudden cardiac death, and ziprasidone labeling advises against other QT-prolonging drugs.
What this interaction means in plain words
Trifluoperazine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive hERG potassium channel blockade and delayed cardiac repolarization.
What to do
Do not co-prescribe; use one antipsychotic at a time. Check an ECG and electrolytes when switching between them.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Trifluoperazine with Ziprasidone?
MediHelp rates the interaction as contraindicated. Trifluoperazine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both antipsychotics can prolong the QT interval. Using them together increases the risk of torsades de pointes and sudden cardiac death, and ziprasidone labeling advises against other QT-prolonging drugs.
How serious is the interaction between Trifluoperazine and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; use one antipsychotic at a time. Check an ECG and electrolytes when switching between them.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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