Drug interactions
Trihexyphenidyl + Umeclidinium-vilanterol
Severity: Moderate
Trihexyphenidyl and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trihexyphenidyl is a strong systemic anticholinergic that adds to the antimuscarinic effects of inhaled umeclidinium. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
What this interaction means in plain words
Trihexyphenidyl and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Trihexyphenidyl belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity, especially in older patients or those with glaucoma or prostatic hypertrophy, and reduce the anticholinergic burden where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Trihexyphenidyl
Frequently asked questions
Can I take Trihexyphenidyl with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Trihexyphenidyl and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trihexyphenidyl is a strong systemic anticholinergic that adds to the antimuscarinic effects of inhaled umeclidinium. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
How serious is the interaction between Trihexyphenidyl and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients or those with glaucoma or prostatic hypertrophy, and reduce the anticholinergic burden where possible.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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