Drug interactions
Trimagnesium + Verapamil
Severity: Moderate
Trimagnesium and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium can add to the calcium channel blocking effects of verapamil, which may lead to hypotension or muscle weakness. The risk is greater with high magnesium doses, parenteral use or renal impairment.
What this interaction means in plain words
Trimagnesium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive physiological antagonism of calcium-mediated vascular and neuromuscular function.
What to do
Monitor blood pressure and neuromuscular status, and check serum magnesium in patients with renal impairment or high magnesium intake.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Trimagnesium with Verapamil?
MediHelp rates the interaction as moderate. Trimagnesium and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium can add to the calcium channel blocking effects of verapamil, which may lead to hypotension or muscle weakness. The risk is greater with high magnesium doses, parenteral use or renal impairment.
How serious is the interaction between Trimagnesium and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and neuromuscular status, and check serum magnesium in patients with renal impairment or high magnesium intake.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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