Drug interactions
Typhoid vaccine live + Vancomycin
Severity: Minor
Typhoid vaccine live and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vancomycin has no activity against gram-negative bacteria such as Salmonella Typhi, so it is not expected to impair the live oral typhoid vaccine. Oral vancomycin remains in the gut but does not act on this organism.
What this interaction means in plain words
Typhoid vaccine live and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; vancomycin lacks gram-negative activity.
What to do
No delay or change is needed; vaccinate according to the schedule.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Typhoid vaccine live with Vancomycin?
MediHelp rates the interaction as minor. Typhoid vaccine live and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vancomycin has no activity against gram-negative bacteria such as Salmonella Typhi, so it is not expected to impair the live oral typhoid vaccine. Oral vancomycin remains in the gut but does not act on this organism.
How serious is the interaction between Typhoid vaccine live and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No delay or change is needed; vaccinate according to the schedule.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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