Drug interactions
Ulipristal + Venetoclax
Severity: Moderate
Ulipristal and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal may inhibit intestinal P-glycoprotein, which could raise venetoclax exposure. Greater venetoclax exposure increases the risk of neutropenia and tumor lysis syndrome, but the effect is predicted from in vitro data.
What this interaction means in plain words
Ulipristal and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible P-glycoprotein inhibition by ulipristal reduces venetoclax efflux and raises its absorption.
What to do
Monitor blood counts and signs of venetoclax toxicity, and consider a venetoclax dose reduction if a P-gp inhibitor is used per labeling. Prefer a non-interacting alternative if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Ulipristal with Venetoclax?
MediHelp rates the interaction as moderate. Ulipristal and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ulipristal may inhibit intestinal P-glycoprotein, which could raise venetoclax exposure. Greater venetoclax exposure increases the risk of neutropenia and tumor lysis syndrome, but the effect is predicted from in vitro data.
How serious is the interaction between Ulipristal and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of venetoclax toxicity, and consider a venetoclax dose reduction if a P-gp inhibitor is used per labeling. Prefer a non-interacting alternative if feasible.
What other medicines interact with Venetoclax?
MediHelp also lists interactions of Venetoclax with, for example, Clarithromycin, Itraconazole, Ketoconazole. The full list is on the Venetoclax page.
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