Drug interactions
Ulipristal + Voxelotor
Severity: Moderate
Ulipristal and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and may raise ulipristal concentrations. The clinical consequence is uncertain, as ulipristal is usually given as a single dose and increased exposure is usually tolerable.
What this interaction means in plain words
Ulipristal and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voxelotor inhibits CYP3A4, reducing ulipristal metabolism.
What to do
Monitor for ulipristal adverse effects such as headache, nausea and dizziness. Consider an alternative emergency contraceptive if repeated or prolonged dosing is planned.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Ulipristal with Voxelotor?
MediHelp rates the interaction as moderate. Ulipristal and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor can inhibit CYP3A4 and may raise ulipristal concentrations. The clinical consequence is uncertain, as ulipristal is usually given as a single dose and increased exposure is usually tolerable.
How serious is the interaction between Ulipristal and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ulipristal adverse effects such as headache, nausea and dizziness. Consider an alternative emergency contraceptive if repeated or prolonged dosing is planned.
What other medicines interact with Voxelotor?
MediHelp also lists interactions of Voxelotor with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Voxelotor page.
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