Drug interactions
Umeclidinium bromide / vilanterol inhaled + Ziprasidone
Severity: Moderate
Umeclidinium bromide / vilanterol inhaled and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can cause QT prolongation and tachycardia at high exposure, and ziprasidone prolongs the QT interval. The clinical risk from the inhaled dose is modest, but it may add to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Umeclidinium bromide / vilanterol inhaled and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT effects from beta-2 agonist-related hypokalemia and ziprasidone hERG blockade.
What to do
Use the inhaler at the recommended dose without extra doses, and monitor heart rhythm and potassium in patients with cardiac risk factors. Obtain an ECG if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Umeclidinium bromide / vilanterol inhaled and Ziprasidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Umeclidinium bromide / vilanterol inhaled with Ziprasidone?
MediHelp rates the interaction as moderate. Umeclidinium bromide / vilanterol inhaled and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can cause QT prolongation and tachycardia at high exposure, and ziprasidone prolongs the QT interval. The clinical risk from the inhaled dose is modest, but it may add to arrhythmia risk in susceptible patients.
How serious is the interaction between Umeclidinium bromide / vilanterol inhaled and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inhaler at the recommended dose without extra doses, and monitor heart rhythm and potassium in patients with cardiac risk factors. Obtain an ECG if palpitations or syncope occur.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
