Drug interactions
Ustekinumab + Zoster vaccine recombinant
Severity: Minor
Ustekinumab and Zoster vaccine recombinant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may blunt the response to recombinant zoster vaccine, though it is non-live and safe to give. Protection may be reduced.
What this interaction means in plain words
Ustekinumab and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Immunomodulation through IL-12/23 inhibition may reduce vaccine immune response.
What to do
Vaccinate according to guidelines, ideally before starting ustekinumab, and complete both doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Ustekinumab with Zoster vaccine recombinant?
MediHelp rates the interaction as minor. Ustekinumab and Zoster vaccine recombinant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may blunt the response to recombinant zoster vaccine, though it is non-live and safe to give. Protection may be reduced.
How serious is the interaction between Ustekinumab and Zoster vaccine recombinant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate according to guidelines, ideally before starting ustekinumab, and complete both doses.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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