Drug interactions
Vardenafil + Vilanterol / fluticasone furoate inhaled
Severity: Minor
Vardenafil and Vilanterol / fluticasone furoate inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can cause QT prolongation and tachycardia at high exposure. Vardenafil adds a small QT effect, but inhaled vilanterol has low systemic exposure so the overall risk is limited.
What this interaction means in plain words
Vardenafil and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive QT effects from beta-agonist activity and PDE5 inhibition.
What to do
Usually no change is needed. Be cautious in patients with known QT prolongation or arrhythmias and monitor for palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Vardenafil with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as minor. Vardenafil and Vilanterol / fluticasone furoate inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vilanterol, a long-acting beta-agonist, can cause QT prolongation and tachycardia at high exposure. Vardenafil adds a small QT effect, but inhaled vilanterol has low systemic exposure so the overall risk is limited.
How serious is the interaction between Vardenafil and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed. Be cautious in patients with known QT prolongation or arrhythmias and monitor for palpitations.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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