Drug interactions
Vardenafil + Zotepine
Severity: Moderate
Vardenafil and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has alpha-1 blocking and QT-prolonging properties, and vardenafil also causes vasodilation and can prolong the QT interval slightly. Together they may cause hypotension and increase arrhythmia risk.
What this interaction means in plain words
Vardenafil and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from alpha-1 antagonism and PDE5 inhibition, with possible additive QT prolongation.
What to do
Use the lowest vardenafil dose and monitor blood pressure, and consider an ECG in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Vardenafil and Zotepine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Vardenafil with Zotepine?
MediHelp rates the interaction as moderate. Vardenafil and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has alpha-1 blocking and QT-prolonging properties, and vardenafil also causes vasodilation and can prolong the QT interval slightly. Together they may cause hypotension and increase arrhythmia risk.
How serious is the interaction between Vardenafil and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest vardenafil dose and monitor blood pressure, and consider an ECG in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
