Drug interactions
Venlafaxine + Voxelotor
Severity: Minor
Venlafaxine and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may raise concentrations of CYP3A4 substrates, though venlafaxine is cleared mainly via CYP2D6. The effect on venlafaxine is likely small.
What this interaction means in plain words
Venlafaxine and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Venlafaxine belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP3A4 by voxelotor may slightly reduce venlafaxine's minor metabolic pathway.
What to do
No dose change is usually needed; monitor for increased venlafaxine adverse effects such as nausea and hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Venlafaxine and Voxelotor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Venlafaxine with Voxelotor?
MediHelp rates the interaction as minor. Venlafaxine and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and may raise concentrations of CYP3A4 substrates, though venlafaxine is cleared mainly via CYP2D6. The effect on venlafaxine is likely small.
How serious is the interaction between Venlafaxine and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for increased venlafaxine adverse effects such as nausea and hypertension.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
