Drug interactions
Venlafaxine + Warfarin
Severity: Moderate
Venlafaxine and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine reduces platelet serotonin and may increase bleeding risk with warfarin. INR may also rise in some patients.
What this interaction means in plain words
Venlafaxine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Venlafaxine belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Impaired platelet function from serotonin reuptake inhibition adds to warfarin anticoagulation.
What to do
Monitor INR after starting or changing venlafaxine and counsel patients on bleeding signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Venlafaxine with Warfarin?
MediHelp rates the interaction as moderate. Venlafaxine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine reduces platelet serotonin and may increase bleeding risk with warfarin. INR may also rise in some patients.
How serious is the interaction between Venlafaxine and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR after starting or changing venlafaxine and counsel patients on bleeding signs.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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