Drug interactions
Verapamil + Vincristine liposomal
Severity: Moderate
Verapamil and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase vincristine exposure, which can intensify neurotoxicity and constipation or ileus. Data specific to the liposomal form are limited.
What this interaction means in plain words
Verapamil and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein and CYP3A4 by verapamil may reduce vincristine clearance.
What to do
Monitor for peripheral neuropathy, constipation and other vincristine toxicity, and consider an alternative to verapamil if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Verapamil with Vincristine liposomal?
MediHelp rates the interaction as moderate. Verapamil and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may increase vincristine exposure, which can intensify neurotoxicity and constipation or ileus. Data specific to the liposomal form are limited.
How serious is the interaction between Verapamil and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for peripheral neuropathy, constipation and other vincristine toxicity, and consider an alternative to verapamil if toxicity develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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