Drug interactions
Verapamil + Zaleplon
Severity: Minor
Verapamil and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and zaleplon is metabolised mainly by aldehyde oxidase with a minor CYP3A4 contribution. Exposure to zaleplon may rise modestly, with slightly more sedation.
What this interaction means in plain words
Verapamil and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Verapamil belongs to Cardiovascular; Zaleplon belongs to Central Nervous System.
Why it happens
Verapamil weakly reduces the minor CYP3A4 metabolic pathway of zaleplon.
What to do
No dose change is normally required. Counsel the patient about additive drowsiness and next-day impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Verapamil with Zaleplon?
MediHelp rates the interaction as minor. Verapamil and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil is a moderate CYP3A4 inhibitor and zaleplon is metabolised mainly by aldehyde oxidase with a minor CYP3A4 contribution. Exposure to zaleplon may rise modestly, with slightly more sedation.
How serious is the interaction between Verapamil and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally required. Counsel the patient about additive drowsiness and next-day impairment.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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