Drug interactions
Verapamil + Zolpidem
Severity: Minor
Verapamil and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zolpidem is metabolised mainly by CYP3A4, and verapamil may increase its concentrations to a limited degree. This can add to sedation and psychomotor impairment.
What this interaction means in plain words
Verapamil and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Verapamil belongs to Cardiovascular; Zolpidem belongs to Central Nervous System.
Why it happens
Verapamil inhibits CYP3A4-mediated clearance of zolpidem.
What to do
Start with the lowest zolpidem dose and counsel the patient about next-day drowsiness. Reduce the dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Zolpidem
Frequently asked questions
Can I take Verapamil with Zolpidem?
MediHelp rates the interaction as minor. Verapamil and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zolpidem is metabolised mainly by CYP3A4, and verapamil may increase its concentrations to a limited degree. This can add to sedation and psychomotor impairment.
How serious is the interaction between Verapamil and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest zolpidem dose and counsel the patient about next-day drowsiness. Reduce the dose if excessive sedation occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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