Drug interactions
Vilanterol / fluticasone furoate inhaled + Ziprasidone
Severity: Moderate
Vilanterol / fluticasone furoate inhaled and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta-agonist that can cause tachycardia and QT prolongation, and ziprasidone also prolongs the QT interval. The risk from standard inhaled doses is modest, but it matters in patients with cardiac risk factors.
What this interaction means in plain words
Vilanterol / fluticasone furoate inhaled and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT effects from beta-2 agonist-related hypokalemia and ziprasidone hERG blockade.
What to do
Keep to the recommended inhaler dose and monitor heart rhythm and potassium in patients with cardiac risk factors. Obtain an ECG if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Vilanterol / fluticasone furoate inhaled with Ziprasidone?
MediHelp rates the interaction as moderate. Vilanterol / fluticasone furoate inhaled and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta-agonist that can cause tachycardia and QT prolongation, and ziprasidone also prolongs the QT interval. The risk from standard inhaled doses is modest, but it matters in patients with cardiac risk factors.
How serious is the interaction between Vilanterol / fluticasone furoate inhaled and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep to the recommended inhaler dose and monitor heart rhythm and potassium in patients with cardiac risk factors. Obtain an ECG if palpitations or syncope occur.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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