Drug interactions
Vincristine liposomal + Zidovudine
Severity: Moderate
Vincristine liposomal and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zidovudine causes myelosuppression and vincristine adds neurotoxicity and possible hematologic effects, so toxicity may be greater when they are given together. Liposomal vincristine is used in oncology, where blood counts are already at risk.
What this interaction means in plain words
Vincristine liposomal and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hematologic and possibly neurologic toxicity; no pharmacokinetic mechanism established.
What to do
Monitor blood counts and neurologic status closely. Consider an alternative antiretroviral with less marrow toxicity in patients on chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Vincristine liposomal with Zidovudine?
MediHelp rates the interaction as moderate. Vincristine liposomal and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zidovudine causes myelosuppression and vincristine adds neurotoxicity and possible hematologic effects, so toxicity may be greater when they are given together. Liposomal vincristine is used in oncology, where blood counts are already at risk.
How serious is the interaction between Vincristine liposomal and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurologic status closely. Consider an alternative antiretroviral with less marrow toxicity in patients on chemotherapy.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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