Drug interactions
Yohimbine + Ziprasidone
Severity: Moderate
Yohimbine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases sympathetic activity and may cause anxiety, tachycardia and blood pressure changes. Ziprasidone causes sedation and orthostatic hypotension through alpha-1 blockade, so the net effects may be unpredictable and could include opposing effects on sedation and blood pressure.
What this interaction means in plain words
Yohimbine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects on adrenergic and central nervous system activity; the interaction is not well characterized.
What to do
Monitor blood pressure, heart rate and mental status when the two are used together. Adjust doses or discontinue yohimbine if agitation, tachycardia or hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Yohimbine with Ziprasidone?
MediHelp rates the interaction as moderate. Yohimbine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that increases sympathetic activity and may cause anxiety, tachycardia and blood pressure changes. Ziprasidone causes sedation and orthostatic hypotension through alpha-1 blockade, so the net effects may be unpredictable and could include opposing effects on sedation and blood pressure.
How serious is the interaction between Yohimbine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and mental status when the two are used together. Adjust doses or discontinue yohimbine if agitation, tachycardia or hypertension occurs.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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