Drug interactions
Zafirlukast + Zavegepant intranasal
Severity: Minor
Zafirlukast and Zavegepant intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zavegepant is a substrate of the NTCP and OATP1B3 transporters, and inhibitors of these may raise its exposure. It is not established that zafirlukast inhibits NTCP clinically, so the interaction is mainly theoretical.
What this interaction means in plain words
Zafirlukast and Zavegepant intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible transporter inhibition affecting zavegepant disposition; not well established for zafirlukast.
What to do
No routine change is required; monitor for zavegepant adverse effects such as nausea or nasal discomfort.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Zafirlukast and Zavegepant intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Frequently asked questions
Can I take Zafirlukast with Zavegepant intranasal?
MediHelp rates the interaction as minor. Zafirlukast and Zavegepant intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zavegepant is a substrate of the NTCP and OATP1B3 transporters, and inhibitors of these may raise its exposure. It is not established that zafirlukast inhibits NTCP clinically, so the interaction is mainly theoretical.
How serious is the interaction between Zafirlukast and Zavegepant intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required; monitor for zavegepant adverse effects such as nausea or nasal discomfort.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
