Drug interactions
Zafirlukast + Zolpidem
Severity: Minor
Zafirlukast and Zolpidem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast may weakly inhibit CYP3A4, which is the main route of zolpidem metabolism. Any increase in zolpidem exposure is expected to be small, with possible mild extra sedation.
What this interaction means in plain words
Zafirlukast and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Zafirlukast belongs to Respiratory; Zolpidem belongs to Central Nervous System.
Why it happens
Theoretical weak CYP3A4 inhibition by zafirlukast reducing zolpidem clearance.
What to do
No adjustment is routinely needed. Advise patients to report excessive next-day drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Zolpidem
Frequently asked questions
Can I take Zafirlukast with Zolpidem?
MediHelp rates the interaction as minor. Zafirlukast and Zolpidem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast may weakly inhibit CYP3A4, which is the main route of zolpidem metabolism. Any increase in zolpidem exposure is expected to be small, with possible mild extra sedation.
How serious is the interaction between Zafirlukast and Zolpidem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is routinely needed. Advise patients to report excessive next-day drowsiness.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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