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تداخل‌های دارویی

Alvimopan + Codeine

شدت: منع مصرف

Alvimopan and Codeine: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Alvimopan antagonises peripheral mu-opioid receptors, and patients who have taken opioids for more than 7 days can have exaggerated gastrointestinal effects including pain, nausea, vomiting and diarrhea. Short-term perioperative opioid use is not expected to be problematic.

معنای این تداخل به زبان ساده

Alvimopan and Codeine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: High

چرا رخ می‌دهد

Competitive antagonism of peripheral mu-opioid receptors by alvimopan.

اقدام لازم

Do not use alvimopan in patients with therapeutic opioid use for more than 7 consecutive days before starting it. Short-term opioid exposure does not require avoidance.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Alvimopan و Codeine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Alvimopan with Codeine?

MediHelp rates the interaction as contraindicated. Alvimopan and Codeine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan antagonises peripheral mu-opioid receptors, and patients who have taken opioids for more than 7 days can have exaggerated gastrointestinal effects including pain, nausea, vomiting and diarrhea. Short-term perioperative opioid use is not expected to be problematic.

How serious is the interaction between Alvimopan and Codeine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use alvimopan in patients with therapeutic opioid use for more than 7 consecutive days before starting it. Short-term opioid exposure does not require avoidance.

What other medicines interact with Codeine?

MediHelp also lists interactions of Codeine with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Codeine page.

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