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تداخل‌های دارویی

Codeine + Isocarboxazid

شدت: منع مصرف

Codeine and Isocarboxazid: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

MAO inhibitors given with opioids have caused severe reactions including serotonin syndrome-like excitation, hypertension or hypotension, hyperpyrexia and coma. Codeine labeling advises against use during or shortly after MAOI therapy.

معنای این تداخل به زبان ساده

Codeine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Codeine belongs to Musculoskeletal; Isocarboxazid belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

MAO inhibition increases monoamine levels and potentiates opioid effects, with an incompletely understood mechanism.

اقدام لازم

Do not use codeine with isocarboxazid or within 14 days of stopping an MAOI. Choose a non-opioid or alternative analgesic.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Codeine و Isocarboxazid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Codeine with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Codeine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO inhibitors given with opioids have caused severe reactions including serotonin syndrome-like excitation, hypertension or hypotension, hyperpyrexia and coma. Codeine labeling advises against use during or shortly after MAOI therapy.

How serious is the interaction between Codeine and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use codeine with isocarboxazid or within 14 days of stopping an MAOI. Choose a non-opioid or alternative analgesic.

What other medicines interact with Codeine?

MediHelp also lists interactions of Codeine with, for example, Alvimopan, Olanzapine / samidorphan, Phenelzine. The full list is on the Codeine page.

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