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Amitriptyline + Liothyronine

شدت: متوسط

Amitriptyline and Liothyronine: moderate interaction.

آخرین به‌روزرسانی

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خلاصه

Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.

معنای این تداخل به زبان ساده

Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amitriptyline belongs to Central Nervous System; Liothyronine belongs to Endocrine.

سطح شواهد: Moderate

چرا رخ می‌دهد

Increased adrenergic receptor sensitivity from thyroid hormone augments tricyclic cardiovascular and CNS effects.

اقدام لازم

Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.

از داروساز چه بپرسید

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amitriptyline و Liothyronine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amitriptyline with Liothyronine?

MediHelp rates the interaction as moderate. Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.

How serious is the interaction between Amitriptyline and Liothyronine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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