Drug interactions
Amitriptyline + Liothyronine
Severity: Moderate
Amitriptyline and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.
What this interaction means in plain words
Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Liothyronine belongs to Endocrine.
Why it happens
Increased adrenergic receptor sensitivity from thyroid hormone augments tricyclic cardiovascular and CNS effects.
What to do
Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicated
- Amitriptyline + Methylene blue Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amitriptyline + Safinamide Contraindicated
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
- Cholestyramine + Liothyronine Moderate
Frequently asked questions
Can I take Amitriptyline with Liothyronine?
MediHelp rates the interaction as moderate. Amitriptyline and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase sensitivity to catecholamines and may enhance the effects of tricyclics. Reports describe increased cardiac arrhythmias and CNS stimulation. Tricyclic effect may also be accelerated when thyroid hormone is added in depression.
How serious is the interaction between Amitriptyline and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and mental state, and keep thyroid doses stable. Consider an ECG in patients with cardiac disease.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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