تداخل‌های دارویی
Amphotericin b deoxycholate + Streptomycin
شدت: شدید
Amphotericin b deoxycholate and Streptomycin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
معنای این تداخل به زبان ساده
Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Additive nephrotoxicity, with impaired renal function increasing aminoglycoside accumulation and ototoxicity.
اقدام لازم
Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amphotericin b deoxycholate و Streptomycin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Streptomycin
پرسش‌های متداول
Can I take Amphotericin b deoxycholate with Streptomycin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
How serious is the interaction between Amphotericin b deoxycholate and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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