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تداخل‌های دارویی

Apraclonidine + Rasagiline

شدت: شدید

Apraclonidine and Rasagiline: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Apraclonidine labeling advises against use in patients taking MAO inhibitors. Theoretically, MAO inhibition could alter catecholamine handling and cause blood pressure changes, though ophthalmic systemic exposure is small.

معنای این تداخل به زبان ساده

Apraclonidine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apraclonidine belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.

سطح شواهد: Low

چرا رخ می‌دهد

Not firmly established; reduced catecholamine metabolism by MAO inhibition may potentiate the cardiovascular effects of the alpha-2 agonist.

اقدام لازم

Avoid apraclonidine in patients on rasagiline and select another intraocular pressure agent. If unavoidable, monitor blood pressure and heart rate.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Apraclonidine و Rasagiline، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Apraclonidine with Rasagiline?

MediHelp rates the interaction as major. Apraclonidine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine labeling advises against use in patients taking MAO inhibitors. Theoretically, MAO inhibition could alter catecholamine handling and cause blood pressure changes, though ophthalmic systemic exposure is small.

How serious is the interaction between Apraclonidine and Rasagiline?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on rasagiline and select another intraocular pressure agent. If unavoidable, monitor blood pressure and heart rate.

What other medicines interact with Rasagiline?

MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.

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