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تداخل‌های دارویی

Apraclonidine + Phenelzine

شدت: شدید

Apraclonidine and Phenelzine: major interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Apraclonidine labeling lists MAO inhibitors as a contraindication. MAOIs may interfere with catecholamine metabolism and alter blood pressure responses to the alpha-agonist, though systemic exposure from ophthalmic use is low.

معنای این تداخل به زبان ساده

Apraclonidine and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apraclonidine belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.

سطح شواهد: Low

چرا رخ می‌دهد

Not well established; possible altered catecholamine handling due to MAO inhibition with an alpha-2 agonist.

اقدام لازم

Avoid per labeling and choose another intraocular pressure-lowering agent. If unavoidable, monitor blood pressure.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Apraclonidine و Phenelzine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Apraclonidine with Phenelzine?

MediHelp rates the interaction as major. Apraclonidine and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apraclonidine labeling lists MAO inhibitors as a contraindication. MAOIs may interfere with catecholamine metabolism and alter blood pressure responses to the alpha-agonist, though systemic exposure from ophthalmic use is low.

How serious is the interaction between Apraclonidine and Phenelzine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid per labeling and choose another intraocular pressure-lowering agent. If unavoidable, monitor blood pressure.

What other medicines interact with Phenelzine?

MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.

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