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تداخل‌های دارویی

Bcg vaccine live + Leflunomide

شدت: منع مصرف

Bcg vaccine live and Leflunomide: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.

معنای این تداخل به زبان ساده

Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: Moderate

چرا رخ می‌دهد

Suppressed lymphocyte function impairs control of live attenuated organisms.

اقدام لازم

Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Bcg vaccine live و Leflunomide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Bcg vaccine live with Leflunomide?

MediHelp rates the interaction as contraindicated. Bcg vaccine live and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Leflunomide-induced immunosuppression can allow a live attenuated vaccine strain to replicate uncontrolled, causing disseminated infection. The vaccine response may also be diminished.

How serious is the interaction between Bcg vaccine live and Leflunomide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during leflunomide therapy and until drug elimination is confirmed (washout with cholestyramine if needed); give them before starting treatment.

What other medicines interact with Leflunomide?

MediHelp also lists interactions of Leflunomide with, for example, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Leflunomide page.

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