تداخل‌های دارویی
Leflunomide + Smallpox vaccine live
شدت: منع مصرف
Leflunomide and Smallpox vaccine live: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Live vaccinia vaccine can cause progressive vaccinia and serious generalised infection in immunosuppressed patients. Leflunomide impairs the lymphocyte response needed to contain the virus. The vaccine response may also be inadequate.
معنای این تداخل به زبان ساده
Leflunomide and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
Leflunomide's immunosuppression via dihydroorotate dehydrogenase inhibition permits uncontrolled replication of live vaccinia virus.
اقدام لازم
Avoid live smallpox vaccine in patients taking leflunomide unless the risk of exposure clearly outweighs the risk, with specialist input. Consider drug elimination before vaccination when the vaccine is essential.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Leflunomide و Smallpox vaccine live، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Leflunomide
- Bcg vaccine live + Leflunomide منع مصرف
- Influenza virus vaccine quadrivalent intranasal + Leflunomide منع مصرف
- Leflunomide + Measles mumps and rubella vaccine live منع مصرف
- Leflunomide + Measles mumps rubella and varicella vaccine live منع مصرف
- Leflunomide + Measles vaccine منع مصرف
- Alefacept + Leflunomide شدید
پرسش‌های متداول
Can I take Leflunomide with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Leflunomide and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live vaccinia vaccine can cause progressive vaccinia and serious generalised infection in immunosuppressed patients. Leflunomide impairs the lymphocyte response needed to contain the virus. The vaccine response may also be inadequate.
How serious is the interaction between Leflunomide and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live smallpox vaccine in patients taking leflunomide unless the risk of exposure clearly outweighs the risk, with specialist input. Consider drug elimination before vaccination when the vaccine is essential.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
