Drug interactions
Bromocriptine + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat strongly inhibits CYP3A4, the main route of bromocriptine metabolism, so bromocriptine exposure can increase substantially. Effects include hypotension, nausea, somnolence and possible ergot-type vasospasm.
What this interaction means in plain words
Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4-mediated metabolism of bromocriptine by cobicistat.
What to do
Avoid the combination if possible or reduce the bromocriptine dose and titrate slowly. Monitor blood pressure and for symptoms of vasospasm or excess dopaminergic effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat strongly inhibits CYP3A4, the main route of bromocriptine metabolism, so bromocriptine exposure can increase substantially. Effects include hypotension, nausea, somnolence and possible ergot-type vasospasm.
How serious is the interaction between Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or reduce the bromocriptine dose and titrate slowly. Monitor blood pressure and for symptoms of vasospasm or excess dopaminergic effects.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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