تداخل‌های دارویی
Caffeine + Fezolinetant
شدت: شدید
Caffeine and Fezolinetant: major interaction.
آخرین به‌روزرسانی
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خلاصه
Fezolinetant is cleared mainly by CYP1A2, and caffeine is a CYP1A2 substrate that can compete for this enzyme. Reduced clearance could raise fezolinetant exposure and increase the risk of adverse effects including liver injury. The labeled contraindication concerns CYP1A2 inhibitors; ordinary dietary caffeine is a weak interaction, but it is flagged here.
معنای این تداخل به زبان ساده
Caffeine and Fezolinetant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caffeine belongs to Miscellaneous; Fezolinetant belongs to Endocrine.
چرا رخ می‌دهد
Competition for CYP1A2 metabolism may reduce fezolinetant clearance and increase its plasma concentrations.
اقدام لازم
Counsel patients to limit caffeine intake, especially high doses or caffeine-containing medicines, during fezolinetant therapy. Monitor liver tests per fezolinetant labeling and for adverse effects.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Caffeine و Fezolinetant، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Caffeine
تداخلات دیگر Fezolinetant
- Cimetidine + Fezolinetant منع مصرف
- Ciprofloxacin + Fezolinetant منع مصرف
- Desogestrel-ethinyl estradiol + Fezolinetant منع مصرف
- Estradiol + Fezolinetant منع مصرف
- Ethinyl estradiol-drospirenone + Fezolinetant منع مصرف
- Ethinyl estradiol-levonorgestrel + Fezolinetant منع مصرف
پرسش‌های متداول
Can I take Caffeine with Fezolinetant?
MediHelp rates the interaction as major. Caffeine and Fezolinetant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fezolinetant is cleared mainly by CYP1A2, and caffeine is a CYP1A2 substrate that can compete for this enzyme. Reduced clearance could raise fezolinetant exposure and increase the risk of adverse effects including liver injury. The labeled contraindication concerns CYP1A2 inhibitors; ordinary dietary caffeine is a weak interaction, but it is flagged here.
How serious is the interaction between Caffeine and Fezolinetant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to limit caffeine intake, especially high doses or caffeine-containing medicines, during fezolinetant therapy. Monitor liver tests per fezolinetant labeling and for adverse effects.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Methylenedioxymethamphetamine, Selegiline transdermal. The full list is on the Caffeine page.
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