تداخل‌های دارویی
Capecitabine + Leucovorin
شدت: شدید
Capecitabine and Leucovorin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Leucovorin stabilizes the binding of the active fluorouracil metabolite to thymidylate synthase, which enhances the cytotoxic effect of fluoropyrimidines. This can increase toxicities of capecitabine such as diarrhea, mucositis, hand-foot syndrome and myelosuppression.
معنای این تداخل به زبان ساده
Capecitabine and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capecitabine belongs to Oncology; Leucovorin belongs to Miscellaneous.
چرا رخ می‌دهد
Leucovorin increases reduced folate pools, stabilizing the fluorodeoxyuridylate-thymidylate synthase complex and potentiating fluoropyrimidine activity.
اقدام لازم
Avoid combining unless it is part of a specifically designed regimen, as capecitabine labeling advises caution. If used, monitor closely for severe diarrhea and myelosuppression and reduce the capecitabine dose as needed.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Capecitabine و Leucovorin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Capecitabine
تداخلات دیگر Leucovorin
پرسش‌های متداول
Can I take Capecitabine with Leucovorin?
MediHelp rates the interaction as major. Capecitabine and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leucovorin stabilizes the binding of the active fluorouracil metabolite to thymidylate synthase, which enhances the cytotoxic effect of fluoropyrimidines. This can increase toxicities of capecitabine such as diarrhea, mucositis, hand-foot syndrome and myelosuppression.
How serious is the interaction between Capecitabine and Leucovorin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless it is part of a specifically designed regimen, as capecitabine labeling advises caution. If used, monitor closely for severe diarrhea and myelosuppression and reduce the capecitabine dose as needed.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
