تداخل‌های دارویی
Fluorouracil + Leucovorin
شدت: شدید
Fluorouracil and Leucovorin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Leucovorin is deliberately combined with fluorouracil to enhance its cytotoxic effect, but it also increases fluorouracil toxicity, particularly diarrhea, mucositis and myelosuppression. Severe gastrointestinal toxicity can be dangerous, especially in older patients.
معنای این تداخل به زبان ساده
Fluorouracil and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluorouracil belongs to Oncology; Leucovorin belongs to Miscellaneous.
چرا رخ می‌دهد
Leucovorin supplies reduced folate that stabilizes the binding of fluorodeoxyuridylate to thymidylate synthase, enhancing both efficacy and toxicity.
اقدام لازم
Use established regimen doses of fluorouracil when combined with leucovorin and monitor blood counts and for diarrhea and mucositis. Interrupt therapy and reduce the dose for significant toxicity.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fluorouracil و Leucovorin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Fluorouracil
تداخلات دیگر Leucovorin
پرسش‌های متداول
Can I take Fluorouracil with Leucovorin?
MediHelp rates the interaction as major. Fluorouracil and Leucovorin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Leucovorin is deliberately combined with fluorouracil to enhance its cytotoxic effect, but it also increases fluorouracil toxicity, particularly diarrhea, mucositis and myelosuppression. Severe gastrointestinal toxicity can be dangerous, especially in older patients.
How serious is the interaction between Fluorouracil and Leucovorin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use established regimen doses of fluorouracil when combined with leucovorin and monitor blood counts and for diarrhea and mucositis. Interrupt therapy and reduce the dose for significant toxicity.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
