تداخل‌های دارویی
Capecitabine + Telotristat etiprate
شدت: متوسط
Capecitabine and Telotristat etiprate: moderate interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
معنای این تداخل به زبان ساده
Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Telotristat etiprate belongs to Gastrointestinal Tract.
چرا رخ می‌دهد
Possible modulation of CES2-mediated metabolism of capecitabine; the effect has not been clearly established clinically.
اقدام لازم
Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Capecitabine و Telotristat etiprate، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Telotristat etiprate
تداخلات دیگر Capecitabine
پرسش‌های متداول
Can I take Capecitabine with Telotristat etiprate?
MediHelp rates the interaction as moderate. Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
How serious is the interaction between Capecitabine and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Everolimus, Flutamide. The full list is on the Telotristat etiprate page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
