Drug interactions
Capecitabine + Telotristat etiprate
Severity: Moderate
Capecitabine and Telotristat etiprate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
What this interaction means in plain words
Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Telotristat etiprate belongs to Gastrointestinal Tract.
Why it happens
Possible modulation of CES2-mediated metabolism of capecitabine; the effect has not been clearly established clinically.
What to do
Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telotristat etiprate
- Bupropion + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
- Octreotide + Telotristat etiprate Moderate
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Telotristat etiprate?
MediHelp rates the interaction as moderate. Capecitabine and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat etiprate is a prodrug and its metabolites may affect carboxylesterase 2 (CES2) activity. Capecitabine depends on carboxylesterase for conversion to its active form, so exposure and effect could change. The clinical significance is not well established.
How serious is the interaction between Capecitabine and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced capecitabine efficacy and for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression when starting or stopping telotristat.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Everolimus, Flutamide. The full list is on the Telotristat etiprate page.
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