تداخل‌های دارویی
Ceftazidime + Tobramycin
شدت: متوسط
Ceftazidime and Tobramycin: moderate interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with ceftazidime is modest and mainly relevant in patients with renal impairment, older age or dehydration.
معنای این تداخل به زبان ساده
Ceftazidime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftazidime belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
چرا رخ می‌دهد
Possible additive nephrotoxicity, with reduced renal function leading to higher aminoglycoside exposure and greater ototoxic potential.
اقدام لازم
Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Ceftazidime و Tobramycin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Ceftazidime
تداخلات دیگر Tobramycin
پرسش‌های متداول
Can I take Ceftazidime with Tobramycin?
MediHelp rates the interaction as moderate. Ceftazidime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with ceftazidime is modest and mainly relevant in patients with renal impairment, older age or dehydration.
How serious is the interaction between Ceftazidime and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.
What other medicines interact with Ceftazidime?
MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.
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